AGENTS FOR DEFENSE AGAINST CHEMICAL WARFARE: REACTIVATORS OF ACETYLCHOLINESTERASE INHIBITED WITH NEUROTOXIC ORGANOPHOSPHORUS COMPOUNDS
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چکیده
منابع مشابه
New Cinchona Oximes Evaluated as Reactivators of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Organophosphorus Compounds.
For the last six decades, researchers have been focused on finding efficient reactivators of organophosphorus compound (OP)-inhibited acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). In this study, we have focused our research on a new oxime scaffold based on the Cinchona structure since it was proven to fit the cholinesterases active site and reversibly inhibit their activity. Thr...
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Gene delivery using an adenoviral system has been effective in introducing therapeutic proteins in vitro and in vivo. This study tested the feasibility of using adenovirus to deliver clinically relevant amounts of butyrylcholinesterase (BChE), a proven bioscavenger of nerve agents. The adenovirus construct expressed full-length mouse BChE. Mice were injected with a single dose of adenovirus (1....
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The biological effects of organophosphorous chemical warfare agents (CWAs) are exerted by inhibition of acetylcholinesterase (AChE), which blocks the hydrolysis of acetylcholine leading to hypercholinergy, seizures, status epilepticus, respiratory/ cardiovascular failure and death. Current investigations show that bio-scavenger therapy, using purified fetal bovine AChE and the more recently tes...
متن کاملA common mechanism for resistance to oxime reactivation of acetylcholinesterase inhibited by organophosphorus compounds.
Administration of oxime therapy is currently the standard approach used to reverse the acute toxicity of organophosphorus (OP) compounds, which is usually attributed to OP inhibition of acetylcholinesterase (AChE). Rate constants for reactivation of OP-inhibited AChE by even the best oximes, such as HI-6 and obidoxime, can vary >100-fold between OP-AChE conjugates that are easily reactivated an...
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ژورنال
عنوان ژورنال: Military Medical Science Letters
سال: 2015
ISSN: 0372-7025,0372-7025
DOI: 10.31482/mmsl.2015.013